a specialised biology

for your health and longevity


Adipose tissue seat of our health

During this last thirteen years, obesity’s incidence and its implication in metabolic and cardiovascular diseases and, more recently, cancer notably of fat submerged organs as stomac, pancreas, colon or kidneys, never stopped growing. But these epidemiological studies revealed an inconsistence if not a weakness of the correlation with the most widespread overweight indicator, the Body Mass Index.

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In the same time, fat revealed a functional and histologic heterogeneity between:

  • A subcutaneous physiological adipose tissue, made of small adipocytes in a poor and well vascularized frame, which is not or sparsely infiltrated by inflammatory cells
  • A visceral dysmetabolic adipose tissue, made of large adipocytes in a dense and fibrous connective frame, which is little vascularized and full of inflammatory cells

Thus, the first asserts itself as a masterchief of ernegetic homeostasis. It controls via the hypothalamus hunger and satiety, prevents and fights lipidic deposits in peripheral tissues (ectopy) and ensures with his metabolic flexibility energy expenditure, locomotor and brain activity, and body temperature regulation between meals. The second one, however, fades hunger and satiety through hypothalamus inflammation, promotes fat deposits generating steatosis, diabetes, cardiovascular diseases and nephropathy.

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Getting old healthy

40 years ago appeared in research laboratories dwarf mice with an extraordinary longevity, 40 to 50% higher than that of wild mice. Those dwarf mice, named AMES and SNELL, which would have not survived outside the safety of laboratory cages, showed mutation on genes controlling the anterior pituitary gland territories which secretes growth hormones including GH, TSH and prolactin.

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The exploration of these mice revealed efficient physiological systems as a great insulin sensitivity and a reduced insulin signalling, a reduced GH/IGF-1 signalling, a decreased innate immunity, a great oxidative stress resistance associated to a high body detoxification capacity.

Yet, not only these physiological characteristics were found in all eukaryotes, from yeast to mammals including insects, but also in humans where, in the last ten years epidemiological studies on centenarians populations revealed the mutation frequency on the hGH/IFG-1 axis, the insulin signalling, and the oxidative stress and toxicants resistance capacity.

Tests


Meet us

LABORATOIRE PHILIPPE AUGUSTE

119 Avenue Philippe Auguste 75011 Paris
Tel. (33)1 43 67 57 00
Fax (33)1 43 79 00 27

Open from monday to thursday from 7:30am to 6:00pm
Saturday from 8:00am to 12:00am

Access : Metro line 2 Philippe Auguste
BUS 76 Philippe Auguste/Charonne stop